Researchers have identified a new gene that is thought to be critical in the regulation of insulin \u2014 the key hormone in diabetes \u2014 from a family with both high and low blood sugar conditions.<\/p>\n
Besides Type 1 or Type 2 diabetes, nearly 1-2 per cent of cases of the blood sugar condition is due to impairment in a gene called MAFA, that can impair production of insulin and also cause insulinomas \u2014 insulin-producing tumours in pancreas, the study showed.<\/p>\n
Insulinomas tumours are typically caused by low blood sugar levels, in contrast to diabetes which leads to high blood sugar levels.<\/p>\n
\u201cWe were initially surprised about the association of two apparently contrasting conditions within the same families \u2014 diabetes which is associated with high blood sugar and insulinomas associated with low blood sugar,\u201d said lead author Marta Korbonits, Professor at the Queen Mary University of London (QMUL).<\/p>\n
\u201cOur research shows that, surprisingly, the same gene defect can impact the insulin-producing beta cells of the pancreas to lead to these two opposing medical conditions,\u201d Korbonits added.<\/p>\n
The study, published in the journal PNAS, also observed that males were more prone to developing diabetes, while insulinomas were more commonly found in females, but the reasons behind this difference are as yet unknown.<\/p>\n
This is the first time a defect in MAFA gene has been linked with a disease. The resultant mutant protein was found to be abnormally stable, having a longer life in the cell, and therefore significantly more abundant in the beta cells than its normal version.<\/p>\n","protected":false},"excerpt":{"rendered":"
Researchers have identified a new gene that is thought to be critical in the regulation of insulin \u2014 the key hormone in diabetes \u2014 from a family with both high and low blood sugar conditions. Besides Type 1 or Type 2 diabetes, nearly 1-2 per cent of cases of the blood sugar condition is due […]<\/p>\n","protected":false},"author":1,"featured_media":18946,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-18945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/18945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/comments?post=18945"}],"version-history":[{"count":1,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/18945\/revisions"}],"predecessor-version":[{"id":18947,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/18945\/revisions\/18947"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media\/18946"}],"wp:attachment":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media?parent=18945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/categories?post=18945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/tags?post=18945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}