Scientists have identified certain DNA variants in women that increase their risk of Irritable Bowel Syndrome (IBS), the most common gastrointestinal disorder.<\/p>\n
More than 10 % of the population, women more than men, suffer from recurrent symptoms including abdominal pain, gas, diarrhoea and constipation, according to a study. The researchers at Karolinska Institutet in Sweden have identified DNA variants that are associated with increased risk of IBS, but only in women.<\/p>\n
In the study, published in the journal Gastroenterology, researchers found DNA variants that are associated with an increased risk of a doctor\u2019s diagnosis of IBS in women but not in men, specifically from a region on chromosome nine previously reported to also influence puberty timing in women (age at first menstruation).<\/p>\n
\u201cAlthough we cannot point to individual genes at this early stage, we believe these results are exciting, as they converge with existing data on female preponderance and a role of sex-hormones in IBS,\u201d said Mauro D\u2019Amato from Karolinska Institutet.<\/p>\n
The researchers used genotype data from more than 300,000 participants in a genome-wide association study (GWAS). They followed up 2,045 patients from IBS expert centres in Sweden, Belgium, the Netherlands, Italy and the US.<\/p>\n
The scientists observed further associations with constipation-predominant IBS as well as harder stools, again only in women.<\/p>\n","protected":false},"excerpt":{"rendered":"
Scientists have identified certain DNA variants in women that increase their risk of Irritable Bowel Syndrome (IBS), the most common gastrointestinal disorder. More than 10 % of the population, women more than men, suffer from recurrent symptoms including abdominal pain, gas, diarrhoea and constipation, according to a study. The researchers at Karolinska Institutet in Sweden […]<\/p>\n","protected":false},"author":1,"featured_media":27228,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-27227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/27227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/comments?post=27227"}],"version-history":[{"count":1,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/27227\/revisions"}],"predecessor-version":[{"id":27229,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/27227\/revisions\/27229"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media\/27228"}],"wp:attachment":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media?parent=27227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/categories?post=27227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/tags?post=27227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}