Researchers have identified 44 genomic variants that have a significant association with depression, an advance that may lead to improved antidepressant medications.<\/p>\n
The study, published in the journal Nature Genetics, is the largest genome-wide association to date of genetic risk factors for major depression.<\/p>\n
Of these 44 loci, 30 are newly discovered while 14 had been identified in previous studies.<\/p>\n
In addition, the study identified 153 significant genes, and found that major depression shared six loci that are also associated with schizophrenia.<\/p>\n
“This study is a game-changer,” said Patrick F Sullivan, a professor at the University of North Carolina (UNC) in the US.<\/p>\n
The results can be used for improved therapies\u2014targets of known antidepressant medications were enriched in the genetic findings, researchers said.<\/p>\n
The genetic basis of depression overlaps importantly with other psychiatric disorders like bipolar disorder and schizophrenia, they said.<\/p>\n
Intriguingly, the genetic basis of depressive disorder also overlaps with that for obesity and multiple measures of sleep quality, including daytime sleepiness, insomnia and tiredness<\/p>\n
\u201cWe show that we all carry genetic variants for depression, but those with a higher burden are more susceptible,” said Naomi Wray, Professorial Research Fellow at the University of Queensland in Australia.<\/p>\n","protected":false},"excerpt":{"rendered":"
Researchers have identified 44 genomic variants that have a significant association with depression, an advance that may lead to improved antidepressant medications. The study, published in the journal Nature Genetics, is the largest genome-wide association to date of genetic risk factors for major depression. Of these 44 loci, 30 are newly discovered while 14 had […]<\/p>\n","protected":false},"author":1,"featured_media":29468,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-29467","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/29467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/comments?post=29467"}],"version-history":[{"count":1,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/29467\/revisions"}],"predecessor-version":[{"id":29469,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/29467\/revisions\/29469"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media\/29468"}],"wp:attachment":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media?parent=29467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/categories?post=29467"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/tags?post=29467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}