Administering low-dose aspirin a commonly used medication to treat pain, fever, or inflammation may help in reducing plaques in the brain, reducing Alzheimer\u2019s disease pathology as well as protecting memory, reveals a study led by Indian-origin researcher. The findings showed that the common over-the-counter medication decreases amyloid plaque major signs of Alzheimer\u2019s disease pathology in mice by stimulating lysosomes the component of animal cells that help clear cellular debris. \u201cThe study identifies a possible new role for one of the most widely used, common, over-the-counter medications in the world,\u201d said senior author and lead research investigator Kalipada Pahan from Department of Neurological Sciences, Rush Medical College.<\/p>\n
\u201cThe research adds another potential benefit to aspirin\u2019s already established uses for pain relief and for the treatment of cardiovascular diseases,\u201d Pahan said. In the study, published in Journal of Neuroscience, the team gave aspirin orally for a month to genetically modified mice with Alzheimer\u2019s pathology, then evaluated the amount of amyloid plaque in the parts of the brain affected most by Alzheimer\u2019s disease.<\/p>\n
The results showed that the aspirin medications augmented TFEB a protein considered as the master regulator of waste removal, stimulated lysosomes and decreased amyloid plaque pathology in the mice. \u201cUnderstanding how plaques are cleared is important to developing effective drugs that stop the progression of Alzheimer\u2019s disease,\u201d Pahan explained.<\/p>\n
However, experts have questioned the potential of aspirin, citing the failure of several major recent human trials into drugs that reduce amyloid plaques. \u201cA number of compounds have achieved this level of amyloid reduction in mice, yet have subsequently failed in clinical trials in humans,\u201d Clive Ballard, from the University of Exeter, was quoted as saying to the newatlas.com.<\/p>\n
\u201cThe failures may be as a result of the differences between Alzheimer mice and human pathology, and the poor translation of benefits into humans,\u201d he said. Moreover, in human clinical trials, the drug was found to have \u201cno beneficial effects on outcome measures and was associated with an increased risk of gastrointestinal haemorrhage,\u201d noted Rob Howard, from the University College London.<\/p>\n","protected":false},"excerpt":{"rendered":"
Administering low-dose aspirin a commonly used medication to treat pain, fever, or inflammation may help in reducing plaques in the brain, reducing Alzheimer\u2019s disease pathology as well as protecting memory, reveals a study led by Indian-origin researcher. The findings showed that the common over-the-counter medication decreases amyloid plaque major signs of Alzheimer\u2019s disease pathology in […]<\/p>\n","protected":false},"author":1,"featured_media":36102,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-36101","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/36101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/comments?post=36101"}],"version-history":[{"count":1,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/36101\/revisions"}],"predecessor-version":[{"id":36103,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/36101\/revisions\/36103"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media\/36102"}],"wp:attachment":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media?parent=36101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/categories?post=36101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/tags?post=36101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}