Exercise may make body cells healthier and lead to a longer life, a study suggests. The study in mice shows that just one bout of moderate to intense exercise acts as a \u201cstress test\u201d on mitochondria in muscles. Researchers discovered that this \u201cstress test\u201d induced by aerobic exercise triggers a process called mitophagy, where the muscle disposes of the damaged or dysfunctional mitochondria, making the muscle healthier.<\/p>\n
Mitochondria \u2014 the cellular power plant \u2014 creates the fuel so the body can function properly. Yan compared exercise-induced mitophagy to a state vehicle inspection that removes damaged cars from the streets. \u201cAerobic exercise removes damaged mitochondria in skeletal muscle,\u201d said Zhen Yan of the University of Virginia School of Medicine in the US. \u201cIf you do it repeatedly, you keep removing the damaged ones. You have a better muscle with better mitochondrial quality,\u201d said Yan.<\/p>\n
Yan and colleagues assessed the skeletal muscle of a mouse model where they had added a mitochondrial reporter gene called \u201cpMitoTimer.\u201d The mitochondria fluoresce green when they are healthy and turn red when damaged and broken down by the cell\u2019s waste disposal system, the lysosomes. The mice ran on a small treadmill for 90 minutes and researchers observed mitochondrial stress (signs of \u201cstate inspection\u201d) and some mitophagy (towing of the clunkers) at six hours after exercise.<\/p>\n
Yan explained that exercise in these mice also stimulated a kinase called AMPK, which in turn switched on another kinase, Ulk1. These chemical reactions appear to be important in control of the removal of dysfunctional mitochondria. \u201cWhen it is turned on, Ulk1 activates other components in the cell to execute the removal of dysfunctional mitochondria,\u201d Yan said.<\/p>\n","protected":false},"excerpt":{"rendered":"
Exercise may make body cells healthier and lead to a longer life, a study suggests. The study in mice shows that just one bout of moderate to intense exercise acts as a \u201cstress test\u201d on mitochondria in muscles. Researchers discovered that this \u201cstress test\u201d induced by aerobic exercise triggers a process called mitophagy, where the […]<\/p>\n","protected":false},"author":1,"featured_media":5897,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-5896","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/5896","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/comments?post=5896"}],"version-history":[{"count":1,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/5896\/revisions"}],"predecessor-version":[{"id":5898,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/5896\/revisions\/5898"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media\/5897"}],"wp:attachment":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media?parent=5896"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/categories?post=5896"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/tags?post=5896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}