Scientists have identified a mechanism that causes the body to stop creating bone-producing cells with age, a finding that may help develop therapies to treat age-realted bone loss conditions like osteoporosis.<\/p>\n
Osteoporosis – the thinning of bone and the loss of bone density that increases the risk of fractures is a major health problem \u2014 in older people. This is condition is often accompanied by an increase in fat cells in the bone marrow.<\/p>\n
Researchers from University of Alabama at Birmingham in the US found that a protein called Cbf-beta plays a critical role in maintaining the bone-producing cells.<\/p>\n
Furthermore, examination of aged mice showed dramatically reduced levels of Cbf-beta in bone marrow cells, as compared to younger mice, researchers said.<\/p>\n
They found that when this mechanism malfunctions, progenitor cells stop creating bone-producing cells, and instead create fat cells.<\/p>\n
Thus, maintaining Cbf-beta may be essential to preventing human age-associated osteoporosis that is due to elevated creation of fat cells, researchers said.<\/p>\n
The team detailed an underlying mechanism leading to osteoporosis.<\/p>\n
Bone is a living tissue that constantly rebuilds. Bones need a constant new creation of cells specific to their tissue, including the bone-producing cells called osteoblasts.<\/p>\n
Osteoblasts live only about three months and do not divide, researchers said.<\/p>\n
They focused on the molecular mechanism that controls the lineage commitment switch between the osteoblast and adipocyte tracks.<\/p>\n
“The knowledge of this mechanism can provide targets in the search for novel bone-loss therapeutics to treat human osteoporosis with minimal side effects,” they said.<\/p>\n","protected":false},"excerpt":{"rendered":"
Scientists have identified a mechanism that causes the body to stop creating bone-producing cells with age, a finding that may help develop therapies to treat age-realted bone loss conditions like osteoporosis. Osteoporosis – the thinning of bone and the loss of bone density that increases the risk of fractures is a major health problem \u2014 […]<\/p>\n","protected":false},"author":1,"featured_media":5985,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-5984","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/5984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/comments?post=5984"}],"version-history":[{"count":1,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/5984\/revisions"}],"predecessor-version":[{"id":5986,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/5984\/revisions\/5986"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media\/5985"}],"wp:attachment":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media?parent=5984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/categories?post=5984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/tags?post=5984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}