A compound found in soy food products may help suppress the development of breast cancer, paving the way for new therapies to prevent the disease, a study claims.<\/p>\n
Researchers at University of Arizona in the US suggest genistein \u2014 a component of soy foods \u2014 can protect BRCA1, a gene that plays a pivotal role in thwarting tumour development in breast tissue.<\/p>\n
BRCA1 is a tumour-suppressor gene. When working normally, it helps keep DNA stable, protecting against genetic diseases like cancer; when BRCA1 is performing abnormally, the body\u2019s defences against breast cancer are impaired, researchers said.<\/p>\n
A small percentage of breast cancers are caused by mutations in BRCA1, many other breast cancer patients have normal copies, but the genes have been \u201cmethylated\u201d – wrapped in strands of carbon-based molecules that render them unreadable. The BRCA1 gene \u201csilenced\u201d in this manner is unable to do its job as a tumour suppressor, they said.<\/p>\n
One receptor, the aromatic hydrocarbon receptor (AhR), silences BRCA1, triggering a cascade of undesirable effects.<\/p>\n
When BRCA1 is unable to carry out its duties as a tumour suppressor, cancerous cells can proliferate, researchers said.<\/p>\n
The study, published in the journal Current Developments in Nutrition, found that AhR can be targeted by genistein.<\/p>\n
The team hopes this discovery will lead to a genistein-based therapy that can block the harmful actions of AhR.<\/p>\n
One weapon that may be used to target AhR is found in soy, a protein-packed legume that is a major source of compounds called isoflavones, they said.<\/p>\n","protected":false},"excerpt":{"rendered":"
A compound found in soy food products may help suppress the development of breast cancer, paving the way for new therapies to prevent the disease, a study claims. Researchers at University of Arizona in the US suggest genistein \u2014 a component of soy foods \u2014 can protect BRCA1, a gene that plays a pivotal role […]<\/p>\n","protected":false},"author":1,"featured_media":9400,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-9399","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/9399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/comments?post=9399"}],"version-history":[{"count":1,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/9399\/revisions"}],"predecessor-version":[{"id":9401,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/posts\/9399\/revisions\/9401"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media\/9400"}],"wp:attachment":[{"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/media?parent=9399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/categories?post=9399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blastingskyhawk.com\/english\/wp-json\/wp\/v2\/tags?post=9399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}